The purpose of this study is to investigate the effect of SoSikCheongWool-Tang on white rats’ hepatocyte damages induced by Radix Aconitine. For the study, Radix Aconitine was administered to white rats, damaging their hepatocytes, and then SoSikCheongWool-Tang was given to the rats. As a result, the following histological changes of the hepatocytes were observed through light and electron microscope
: 1. Radix Aconitine damaged the congestion, necrosis and hemolysis in the liver.
2. In the six-hour control group, the cisternae of rough and smooth endoplasmic reticula were dilated or disoriented, and the attached ribosomes of rough endoplasmic reticulum were hardly observed.
3. In the three-day control group, the destruction of the nucleus as well as the damage of all the cell-organelles was observed.
4. In all the experiment groups, the rats, after given SoSikCheongWool-Tang, quickly recovered from the cytotoxicity induced by aconitine extracts.
From the above results, this study has come to the conclusion that SoSikCheongWool-Tang is efficacious against the cytotoxicity induced by Radix Aconitine.
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